S-23 Product Details
| Product Name | S-23 |
| Alias | S23 |
| CAS | 1010396-29-8 |
| MF | C18H13ClF4N2O3 |
| MW | 416.75400 |
| Purity | 99.50% |
| Dosage | 10mg to 15mg |
| Grade | Pharmaceutical Grade |
| Appearance | white crystalline powder |
| Standard | USP |
| Usage | Male hormonal contraceptive, increase muscle mass, reduce fat |
S-23 Product Description
Developed by GTx, S-23 is an orally active nonsteroidal SARM with a very high binding affinity to androgen receptors. This makes it stronger than other popular SARMS like Ostabolic (mk-2866) or Andarine (S-4). Therefore, the main effects of S-23 are increased muscle mass, decreased fat mass, and a decrease in the size of the prostate. Additionally, in a study done on rats a dose equivalent to 15 milligrams (mg) for a 180lb male was shown to also increase bone mineral density, as well as promote muscle mass growth and fat loss. Hence, S-23 is versatile in that it can be used for bulking and for cutting. S23 or (2S)-N-(4-cyano-3-trifluoromethylphenyl)-3-(3-fluoro-4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide is a new SARM, which is developed as a possible male hormonal contraceptive. It links to the androgen receptor (AR) more intensely (with a Ki of 1.7nM) as compared to older medicines such as Andarine. As of today, what we know is that S23 is an easy-to-dose oral SARM that can boost lean muscle mass growth while being tissue selective at the same time. Sarms S23 is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc as a potential male hormonal contraceptive. It binds to the androgen receptor more strongly than older drugs such as andarine with a Ki of 1.7 nM, and in animal studies it showed both a good ratio of anabolic to androgenic effects, and dose-dependent suppression of spermatogenesis with spontaneous recovery after cessation of treatment. A 2009 study performed on rats showed potential for S-23 to be used as a male contraceptive. In this study, six rats were given a dose of 0.1 mg per day for 10 weeks. As a result, both LH (Luteinizing Hormone) and FSH (Follicle-Stimulating Hormone) levels decreased. These effects were statistically significant, since four of the six rats had no sperm in the testis. What’s more, none of the rats was able to impregnate a female rat during mating trials. However, this contraceptive effect was temporary – after just 100 days from last dose the infertility was reversed, and there was a 100% pregnancy rate. A high throughput screening campaign was conducted to identify small molecules with the ability to inhibit the interaction between the vitamin D receptor (VDR) and steroid receptor coactivator 2. These inhibitors represent novel molecular probes to modulate gene regulation mediated by VDR. The peroxisome proliferator-activated receptor δ (PPARδ) agonist GW0742 was among the identified VDR-coactivator inhibitors and has been characterized herein as a pan nuclear receptor antagonist at concentrations higher than 12.1 µM. The highest antagonist activity for GW0742 was found for VDR and the androgen receptor (AR). Surprisingly, GW0742 behaved as PPAR agonist/antagonist activating transcription at lower concentration and inhibiting this effect at higher concentrations.S-23 Product Application
S-23 not only boosted muscle mass, but also reduced fat mass, as studied. SARMs have a bit of a 'soft' image in the doping world. They don't stimulate muscle growth in the way that anabolic steroids do, but many users say that they are safer. There are no studies yet that confirm this suspicion. But that S23 is not one of the safer SARMs - we'd be willing to wager a bottle of BCAAs on that. S23 halts the production of sperm in the testes. In fact it does this so well that the researchers suspect S23 might be a good candidate for a male contraceptive. If this is the case it would probably have to be part of a cocktail that also contains an estradiol analogue, the researchers discovered. The lab animals lost their libido when they were given S23 on its own, and only recovered this when they were given estradiol benzoate together with the S23. GW0742 is a synthetic, potent and selective PPAR-β/δ agonist. PPARs are ligand-dependent transcription factors which are involved in many physiological processes, such as inflammation and energy homeostasis. PPAR-β/δ is one of three PPARs in the nuclear hormone receptor superfamily that are collectively involved in the control of lipid homoeostasis among other functions. GW0742 can attenuate the increase of PARP activity that caused by SAO shock. GW0742 is also able to prevent radiation-induced brain injury in C57Bl/6 wild-type (WT) and PPARδ knockout (KO) mice. Dietary GW0742 can prevent the acute increase in IL-1β mRNA and ERK phosphorylation measured at 3 h after a single 10-Gy dose of WBI as well as the increase in the number of activated hippocampal microglia 1 week after WBI.S-23 Product Function
S-23 not only boosted muscle mass, but also reduced fat mass, as studied. SARMs have a bit of a 'soft' image in the doping world. They don't stimulate muscle growth in the way that anabolic steroids do, but many users say that they are safer. There are no studies yet that confirm this suspicion. But that S23 is not one of the safer SARMs - we'd be willing to wager a bottle of BCAAs on that. S23 halts the production of sperm in the testes. In fact it does this so well that the researchers suspect S23 might be a good candidate for a male contraceptive. If this is the case it would probably have to be part of a cocktail that also contains an estradiol analogue, the researchers discovered. The lab animals lost their libido when they were given S23 on its own, and only recovered this when they were given estradiol benzoate together with the S23.S-23 Product Dosage
Dosages of S-23 can vary, and they will be very dependent on what the goal is. For instance, if a user were looking for muscle building and fat loss, a dose of 15-25 mgs per day would be appropriate. On the other hand, if someone was looking to use it for the contraceptive effects, a higher dose of around 50 mgs per day would be more effective. Nonetheless, this is not recommended because there have not been studies done on humans to replicate the contraceptive effect shown in rats.Clients Feedback
Machine Working Shop
Our Advantages
1. More than 5years Rich experience:Our company is a professional production leading factory in China in pharmaceutical area of many years. 2. Discreet package :The packing suits you best would be choosen to cross customs safely. also our warehouse have more than 1hundreds of packing methods ,Or if you have your own ideal way, it could be also taken into consideration . 3. Top quality. High quality guaranteed, once any problem is found, the package would be reshipped for you .and some other products for free . 4. Security Shipping:Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional forwarder would be recommanded for you. 5. Fast delivery:we hare stock ,so we can deliver your order in 4hours when payment information was confirmed. 6. Quality service:we will give you warm after-sale service,if any question we will reply you at once . 7. Competitive prices:big discount under market price ,plz connect me ,a gift is ready for youOrder Process
| Make an order | Please make clear what product and what quantity you need |
| Quote | Prices and Specifications details would be offered for you to consider and confirm |
| Payment ways | Bank Transfer, Western Union, Money Gram and Bitcoin |
| Delivery ways | All Express Modes(EMS, DHL, TNT, FedEx, UPS, etc.) |
| Shipping address | Provide your Valid and Correct destination address info(if possible with post code, phone number). |
| Packing | Select best ways according to quantity and safety degree(Super discreet, professional and experienced) |
| Lead time | Within 8 hours upon receipt of payment |
| Package picture | Photos of package would be offered to tell apart the items |
| Tracking number | Offered once it is released |
| Shipping time | 3-7 working days (Door-to-Door) |
| After-sale service | 24/7 Online for any problems |
FAQ
Q1: Have your Product Quality been Approved by the Third Party Lab? A: Yes, all the products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us. Q2: How do you treat quality complaint? A: First of all, our QC department will do the strict examination of our export products by HPLC, UV, GC , TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem, caused by us, we will send you free goods for replacement or refund your loss. Q3: Do you Accept Sample Order? A: Yes, we can accept small order from 10g, 100g and 1kg for your evaluation quality of our goods. Q4: Is there any discount? A: Yes, for the larger quantity, we always support with better price for our further cooperation. Q5: Do you accept VISA business credit card? A: Sorry we don't accept VISA credit card, but we'd like to accept the bank transfer, Western Union, Paypal or Bitcoin. Q6: How long does it take the goods to arrive? It is Depending on your location, For the small order, please expect the 5-7 days by DHL,UPS,TNT, FEDEX, EMS and so on. For the mass order, please allow the 5-8 days by Air or 20-35 days by Sea. Q7: Do you have any reshipment policy? Of course, we have the good after-sale service and re-shipment policy if the parcel lose. Our long association with our clients has brought great benefits, we always take the upmost care in the packaging of our products. Our clients will confirm this as even they struggle to find them without help at times. But in spite of our best efforts, it is still possible will seize a small number of packages. In this circumstance we promise reship free to establish a long term relationship with each other. Q8: Can I get a sample? A: Of course. For most products, we can provide you a free sample to test the quality, while the shipping cost should be undertook by your side. We have formed a technology and management team that cooperate closely with some overseas Labs all speak highly of our safe shipping and goods. please do not hesitate to contact us.Contact Us
Hjtc (Xiamen) Industry Co., Ltd.
Xiamen Huayongjian Biotechnology Co., Ltd.
Contacts: June & Eason
Whatsapp:+8618206063252; +8618759200098
E-mail: [email protected];
Web site:https://www.steroidpowder-hjtc.com/ http://www.safeststeroid.com/ http://www.glassviallabels.com/ https://hjtc-printing.en.made-in-china.com/
