Clomiphene 50mg Description
Clomid (clomiphene citrate tablets USP) is an orally administered, nonsteroidal, ovulatory stimulant designated chemically as 2-[p-(2-chloro-1,2-diphenylvinyl)phenoxy] triethylamine citrate (1:1). It has the molecular formula of C26H28ClNO • C6H8O7 and a molecular weight of 598.09. It is represented structurally as:
Clomiphene 50mg Clinical Pharmacology
Action
Clomid is a drug of considerable pharmacologic potency. With careful selection and proper management of the patient, Clomid has been demonstrated to be a useful therapy for the anovulatory patient desiring pregnancy. Clomiphene citrate is capable of interacting with estrogen-receptor-containing tissues, including the hypothalamus, pituitary, ovary, endometrium, vagina, and cervix. It may compete with estrogen for estrogen-receptor-binding sites and may delay replenishment of intracellular estrogen receptors. Clomiphene citrate initiates a series of endocrine events culminating in a preovulatory gonadotropin surge and subsequent follicular rupture. The first endocrine event in response to a course of clomiphene therapy is an increase in the release of pituitary gonadotropins. This initiates steroidogenesis and folliculogenesis, resulting in growth of the ovarian follicle and an increase in the circulating level of estradiol. Following ovulation, plasma progesterone and estradiol rise and fall as they would in a normal ovulatory cycle. Available data suggest that both the estrogenic and antiestrogenic properties of clomiphene may participate in the initiation of ovulation. The two clomiphene isomers have been found to have mixed estrogenic and antiestrogenic effects, which may vary from one species to another. Some data suggest that zuclomiphene has greater estrogenic activity than enclomiphene. Clomiphene citrate has no apparent progestational, androgenic, or antiandrogenic effects and does not appear to interfere with pituitary-adrenal or pituitary-thyroid function. Although there is no evidence of a "carryover effect" of Clomid, spontaneous ovulatory menses have been noted in some patients after Clomid therapy.Pharmacokinetics
Based on early studies with 14C-labeled clomiphene citrate, the drug was shown to be readily absorbed orally in humans and excreted principally in the feces. Cumulative urinary and fecal excretion of the 14C averaged about 50% of the oral dose and 37% of an intravenous dose after 5 days. Mean urinary excretion was approximately 8% with fecal excretion of about 42%. Some 14C label was still present in the feces 6 weeks after administration. Subsequent single-dose studies in normal volunteers showed that zuclomiphene (cis) has a longer half-life than enclomiphene (trans). Detectable levels of zuclomiphene persisted for longer than a month in these subjects. This may be suggestive of stereo-specific enterohepatic recycling or sequestering of the zuclomiphene. Thus, it is possible that some active drug may remain in the body during early pregnancy in women who conceive in the menstrual cycle during Clomid therapy.Clomiphene 50mg Specifications
| Test Items | Specification | Test Results |
| Appearance | White or off-white powder | white powder |
| Identification | UV conform | Conforms |
| Organic nitrogenous | Conforms | Conforms |
| Citrate | Conforms | Conforms |
| Water | Not more than 1.0% | 0.35% |
| Heavy water | Not more than 0.002% | Conforms |
| Related impuries | Related compound A:Not more than 2.0% | 0.84% |
| Individual:Not more than 0.5% | 0.36% | |
| (Z)isomer | Conforms | Conforms |
| Organicvolatile impuritise | Conforms | |
| Assay | Between98.0~102.0% | 99.5% |
Clomiphene 50mg Clinical Studies
During clinical investigations, 7578 patients received Clomid, some of whom had impediments to ovulation other than ovulatory dysfunction . In those clinical trials, successful therapy characterized by pregnancy occurred in approximately 30% of these patients. There were a total of 2635 pregnancies reported during the clinical trial period. Of those pregnancies, information on outcome was only available for 2369 of the cases. Table 1 summarizes the outcome of these cases. Of the reported pregnancies, the incidence of multiple pregnancies was 7.98%: 6.9% twin, 0.5% triplet, 0.3% quadruplet, and 0.1% quintuplet. Of the 165 twin pregnancies for which sufficient information was available, the ratio of monozygotic to dizygotic twins was about 1:5. Table 1 reports the survival rate of the live multiple births. A sextuplet birth was reported after completion of original clinical studies; none of the sextuplets survived (each weighed less than 400 g), although each appeared grossly normal.| Table 1. Outcome of Reported Pregnancies in Clinical Trials (n = 2369) | ||
|---|---|---|
| Includes 28 ectopic pregnancies, 4 hydatiform moles, and 1 fetus papyraceous. Indicates percentage of surviving infants from these pregnancies. | ||
| Pregnancy Wastage | ||
| Spontaneous Abortions | 483* | |
| Stillbirths | 24 | |
| Live Births | ||
| Single Births | 1697 | 98.16%† |
| Multiple Births | 165 | 83.25%† |
R&D Center
OUR ADWANTAGE
1,High quality with competitive price: 1)Standard: USP Standard 2)All Purity≥99% 3)We are manufacturer and can provide high quality products with factory price. 2,Fast and safe delivery 1)Parcel can be sent out in 24 hours after payment. Tracking number available 2)Secure and discreet shipment. Various transportation methods for your choice. 3)Customs pass rate ≥99% 4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring. 3,We have clients throughout the world. 1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire. 2)Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility. 3) High quality,competitive price,fast delivery ,first-class service gain the trust and praise from the customers.After Sales Service
1. Any inquiries will be replied within 24 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. OEM/ODM Available. 5. Reasonable & competitive price, fast lead time. 6. Sample is available for your evaluation & formulation development.FAQ
Q1:How to confirm the Product Quality before placing orders? A:free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future. Q2:Can you give me a discount price? A:Surely,It depend on your qty.Larger order can enjoy cheaper price. Q3:When you ship my order? A:Normally within 2 to 3 days after confirming your payment,because we need time to arrange Stealth Packing for 100% customs clearance. Q4:Can you guarantee I can get my goods without any custom problem? Yes, We have Reship Service.You can get your goods without any problem. Q5:How do you treat quality complaint? A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us,we will send you free goods for replacement or refund your loss. Q6:Which kind of payment terms do you accept? A:For any order,you can pay by Paypal,Bitcoin,T/T,Western Union or Money Gram. Q7: How to contact with us? A:We use email, whatsapp, wickr me, wechat,ect. so pls be free to contact me if you have any needs.Finished Tablets
| ID | Item | Capacity |
| 1 | Clenbuterol | 40mcg*100/bottle |
| 2 | Clomid(Clomiphene) | 50mg*100/bottle |
| 3 | Letrozle(Femara) | 2.5mg*100/bottle |
| 4 | Halotestin(Fluoxymesterone) | 10mg*100/bottle |
| 5 | Dianabol(Methandrostenolone) | 10mg*100/bottle |
| 6 | Dianabol(Methandrostenolone) | 20mg*100/bottle |
| 7 | Dianabol(Methandrostenolone) | 50mg*100/bottle |
| 8 | Proviron(Mesterolone) | 10mg*100/bottle |
| 9 | Proviron(Mesterolone) | 25mg*100/bottle |
| 10 | Primobolan(Methenolone Acetate) | 10mg*100/bottle |
| 11 | Primobolan(Methenolone Acetate) | 25mg*100/bottle |
| 12 | Primobolan(Methenolone Acetate) | 50mg*100/bottle |
| 13 | Superdrol(Methasterone) | 10mg*100/bottle |
| 14 | T3(Liothytonine Sodium) | 25mcg*100/bottle |
| 15 | T3(Liothytonine Sodium) | 40mcg*100/bottle |
| 16 | T4 | 40mcg*100/bottle |
| 17 | Anavar(Oxandrolone) | 10mg*100/bottle |
| 18 | Anavar(Oxandrolone) | 25mg*100/bottle |
| 19 | Anavar(Oxandrolone) | 50mg*100/bottle |
| 20 | Anadrol(Oxymetholone) | 50mg*100/bottle |
| 21 | Winstrol(Stanozolol) | 10mg*100/bottle |
| 22 | Winstrol(Stanozolol) | 20mg*100/bottle |
| 23 | Winstrol(Stanozolol) | 50mg*100/bottle |
| 24 | Turinabol(Chlordehydromethyltestosterone) | 10mg*100/bottle |
| 25 | Turinabol(Chlordehydromethyltestosterone) | 25mg*100/bottle |
| 26 | Nolvadex(Tamoxifen) | 10mg*100/bottle |
| 27 | Nolvadex(Tamoxifen) | 20mg*100/bottle |
| 28 | Aromasin(Exemestane) | 25mg*100/bottle |
| 29 | Arimidex(Anastrozole) | 1mg*100/bottle |
| 30 | Viagra(Sildenafil) | 100mg*100/bottle |
| 31 | Cialis(Tadanafil) | 20mg*100/bottle |
Contact Us
Hjtc (Xiamen) Industry Co., Ltd.
Xiamen Huayongjian Biotechnology Co., Ltd.
Contacts: June & Eason
Whatsapp:+8618206063252; +8618759200098
E-mail: [email protected];
Web site:https://www.steroidpowder-hjtc.com/ http://www.safeststeroid.com/ http://www.glassviallabels.com/ https://hjtc-printing.en.made-in-china.com/
